Key result
A mathematical model of fluid and solute exchange in humans showed very good agreement with experimental data from normal and 10% haemorrhaged subjects receiving saline or hypertonic saline.
Population
Normal individuals and subjects with 10% haemorrhage (data derived from two experimental studies)
Comparison
Mathematical model simulations of fluid and… vs Direct experimental data from the two studies
Design
Other
Authors
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Validated model enables simulation of fluid shifts post-haemorrhage; leaves open clinical translation pending prospective trials.
A mathematical model of fluid and solute exchange was successfully validated against human experimental data, providing a tool to investigate fluid redistribution following haemorrhage and fluid infusion.
Bert et al. (2000) studied Normal individuals and those with acute hypovolemia (10% haemorrhage). Mathematical model of fluid and solute exchange vs. Experimental data was evaluated on Dynamic changes in plasma and interstitial fluid volumes, colloid osmotic pressures, haematocrit, plasma solute concentrations and transcapillary flow rates. A mathematical model of fluid and solute exchange in humans showed very good agreement with experimental data from normal and 10% haemorrhaged subjects receiving saline or hypertonic saline.
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