Key result
Isolated chick cardiac myoblasts treated with cytochalasin-B demonstrated that normal mitotic chromosomal separation and muscle contraction can take place simultaneously.
Population
Isolated chick cardiac myoblasts
Design
Preclinical
Authors
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No direct clinical implications from avian cells; leaves open coordinated motility in mammalian cardiomyocytes.
This study demonstrates that cardiac myoblasts can simultaneously regulate two different motile systems (muscle contraction and chromosomal separation) without interference.
Joseph W. Sanger (1977) studied this question. Cytochalasin-B was evaluated on Mitotic chromosomal separation and muscle contraction. Isolated chick cardiac myoblasts treated with cytochalasin-B demonstrated that normal mitotic chromosomal separation and muscle contraction can take place simultaneously.
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