Key result
Preoxygenation with 8 vital capacity breaths in 1 minute resulted in significantly higher arterial oxygen tension (451.50 vs 400.19 mmHg) compared to 3 minutes of tidal volume breathing in elderly patients.
Why the study?
Tidal volume breathing for 3-5 minutes may not be feasible in emergency situations, warranting evaluation of faster preoxygenation methods like 8 vital capacity breaths in elderly patients.
Does 8 vital capacity breaths in 1 minute improve arterial oxygen tension and apnoea induced desaturation time compared to 3 minutes of tidal volume breathing in elderly patients undergoing general anaesthesia?
RCT (n=60)
Double-blind
Computer generated sequence of random numbers
No
Does 8 vital capacity breaths in 1 minute improve arterial oxygen tension and apnoea induced desaturation time compared to 3 minutes of tidal volume breathing in elderly patients undergoing general anaesthesia?
Absolute Event Rate: 451.5% vs 400.19%
p-value: p=<0.05
In elderly patients undergoing general anaesthesia, 8 vital capacity breaths in 1 minute provides significantly higher arterial oxygen tension and comparable apnoea-induced desaturation time compared to the traditional 3-minute tidal volume breathing technique.
Faster preoxygenation may aid emergencies; leaves open efficacy versus standard tidal-volume methods in broader trials.
Background and Aims: Preoxygenation is performed routinely as an integral part of induction for general anaesthesia to reduce the risk of hypoxia for planned or unplanned periods of apnoea during the induction of anaesthesia. 3-5 minutes of tidal volume preoxygenation is the most preferred technique of choice for preoxygenation. This technique may not be feasible in emergency situations. Faster method of preoxygenation may be more useful and a better alternative in certain clinical conditions like rapid sequence induction, life saving emergencies etc. This study aims to compare the effectiveness between two methods of preoxygenation i.e. 8 vital capacity breath (VCB) in 1 minute and Tidal volume breathing (TVB) for 3 minutes and in elderly patients, by assessing changes in arterial oxygen tension (PaO 2 )and apneoa induced desaturation time. Material and Methods: This prospective randomised controlled double blind study was conducted with 60 elderly patients (age 60-70 yrs) and were divided into 2 groups-Group VCB and Group TVB. After preoxygenation with either method, anaesthesia was induced in all patients. Mask ventilation was not done and following intubation endotracheal tube was kept open to atmosphere. The time taken for the patients to desaturate to 90% was noted and immediately ventilation was resumed. Arterial blood gas samples were taken while patients were breathing room air, immediately after preoxygenation and at 90% desaturation. Results: After preoxygenation group VCB had significant higher PaO 2 values than group TVB( 451.50 68.57 vs 400.19 63.69). The apnoea induced desaturation time for group VCB was 494.77 18.92 secs and group TVB was 506.67 22.70 secs, which was statistical insignificant.
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A 2020 study conducted an RCT in Elective surgery under general anaesthesia (n=60). 8 vital capacity breaths (VCB) vs. Tidal volume breathing (TVB) for 3 minutes with 5 L/min O2 was evaluated on Arterial oxygen tension (PaO2) after preoxygenation (p=<0.05). Preoxygenation with 8 vital capacity breaths in 1 minute resulted in significantly higher arterial oxygen tension (451.50 vs 400.19 mmHg) compared to 3 minutes of tidal volume breathing in elderly patients.
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