Key result
Elevated baseline plasma resistin independently predicted recurrent atrial arrhythmia after catheter ablation, with levels >777 pg/mL predicting recurrence with 70% sensitivity and 68% specificity.
Why the study?
Resistin is linked to inflammation and cardiometabolic diseases, but its role in inflammation and its effect on clinical outcomes after AF catheter ablation needed examination.
Does baseline plasma resistin level predict the recurrence of atrial arrhythmia in patients with drug-refractory atrial fibrillation undergoing catheter ablation?
Cohort (n=108)
No
Does baseline plasma resistin level predict the recurrence of atrial arrhythmia in patients with drug-refractory atrial fibrillation undergoing catheter ablation?
Elevated baseline plasma resistin (≥ 777 pg/mL) is an independent predictor of atrial arrhythmia recurrence after catheter ablation in patients with drug-refractory atrial fibrillation.
Answers are grounded in this paper and cite their sources.
Elevated resistin was associated with post-ablation AF recurrence; leaves open its value for risk stratification pending prospective validation.
Resistin is an adipocytokine that is abundantly secreted from lipid cells and is related to the inflammatory process and cardiometabolic diseases. This study aimed to examine the role of resistin on inflammation and its effect on the clinical outcome of patients with atrial fibrillation (AF) following catheter ablation.A total of 108 patients (56.9 ± 12.0 years, 76.8% male) with symptomatic and drug-refractory AF undergoing catheter ablation were enrolled. Inflammatory biomarkers and epicardial fat volume by contrast computed tomography (CT) images were assessed in all patients before the procedure. Baseline resistin correlated with epicardial fat volume, tumor necrosis factor-α (TNF-α), and left atrial (LA) scar area. After the index procedure, the univariate analysis revealed that hypertension, persistent AF, LA diameter, and plasma resistin level were related to recurrent atrial arrhythmia. Multivariate regression analysis revealed that persistent AF, LA diameter, and plasma resistin level all independently predicted recurrent atrial arrhythmia after ablation. Plasma resistin with a level higher than 777 (pg/mL) could predict recurrence following catheter ablation of AF.High plasma resistin level is associated with poor left atrial substrate, high epicardial fat volume, and elevated TNF-α level in patients with AF. Plasma resistin may predict the recurrence of atrial arrhythmia after ablation.
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Chang et al. (2020) conducted a cohort in Symptomatic and drug-refractory atrial fibrillation (n=108). Plasma resistin level vs. Lower plasma resistin level was evaluated on Recurrent atrial arrhythmia after catheter ablation (95% CI 1.001-1.003, p=0.001). Elevated baseline plasma resistin independently predicted recurrent atrial arrhythmia after catheter ablation, with levels >777 pg/mL predicting recurrence with 70% sensitivity and 68% specificity.
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