Key result
High resistin in LMCA PVAT is linked to ~670% greater POAF risk.
Why the study?
Postoperative atrial fibrillation occurs in up to 30% of patients after CABG and its cause is unknown, prompting investigation of resistin concentration in PVAT.
Does a higher concentration of resistin in perivascular adipose tissue predict postoperative atrial fibrillation in patients undergoing elective CABG?
Observational (n=46)
No
Does a higher concentration of resistin in perivascular adipose tissue predict postoperative atrial fibrillation in patients undergoing elective CABG?
Higher concentrations of resistin in perivascular adipose tissue near the left main coronary artery are strongly associated with the development of postoperative atrial fibrillation after CABG.
Answers are grounded in this paper and cite their sources.
PVAT resistin may flag POAF risk after CABG; leaves open causal role and requires prospective validation before any clinical use.
BACKGROUND: Postoperative atrial fibrillation occurs in up to 30% of patients after coronary artery bypass graft (CABG) and its cause is unknown. The aim of the study was to evaluate whether concentration of resistin in surrounding coronary artery perivascular adipose tissue (PVAT) is related to postoperative atrial fibrillation occurrence. METHODS: A total number of 46 patients (35 male, 11 female; median age 66.5) were qualified for elective CABG. Medical history, laboratory test results and echocardiographic parameters were noted. Patients were monitored up to 3 days after CABG and then were divided into groups with and without postoperative atrial fibrillation occurrence. Fragments of PVAT were collected intra-operatively: near the left anterior descending artery and main left coronary artery. The concentration of resistin was determined by Human Resistin Quantikine ELISA Kit and expressed as ng/g. A multivariate stepwise logistic regression analysis was performed to find variables related to postoperative atrial fibrillation occurrence. RESULTS: Postoperative atrial fibrillation occurred in 14 (30.4%) patients. The patients with and without postoperative atrial fibrillation were similar in age, gender, epicardial adipose tissue thickness and laboratory parameters. The concentration of resistin in PVAT near the left main coronary artery was significantly higher in patients with postoperative atrial fibrillation than in those without the complication (P = 0.03). In the multivariate stepwise logistic regression analysis the concentration of resistin above cut-off point 54 ng/g in PVAT near left main coronary artery was independently related to postoperative atrial fibrillation occurrence (OR: 7.7; 95% CI:1.4-42.2 p = 0.02). CONCLUSIONS: The higher concentrations of resistin in PVAT near the left main coronary artery which is located close to the left atrium are associated with postoperative atrial fibrillation.
No takes yet. Share an insight, caveat, or question.
Rachwalik et al. (2019) conducted an observational in Postoperative atrial fibrillation after CABG (n=46). Resistin concentration > 54 ng/g in perivascular adipose tissue near the left main coronary artery vs. Resistin concentration ≤ 54 ng/g was evaluated on Postoperative atrial fibrillation occurrence (OR 7.7, 95% CI 1.4-42.2, p=0.02). A resistin concentration above 54 ng/g in perivascular adipose tissue near the left main coronary artery was independently associated with an increased risk of postoperative atrial fibrillation (OR 7.7).
Synapse has enriched 10 related papers. Consider them for comparative context: