Key result
Hindlimb-unloaded rats exhibited a significantly greater decrease in renal sympathetic nerve activity in response to volume expansion compared to controls (-46% vs. -25%).
Why the study?
Does hindlimb unloading enhance sympathoinhibitory responses to volume expansion in rats?
Population
Conscious hindlimb-unloaded (HU) rats (14 days) and control animals, a model of cardiovascular deconditioning.
Comparison
Isotonic volume expansion vs Control animals receiving the same volume…
Design
Preclinical
Authors
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Augmented sympathoinhibition to volume expansion in unloaded rats; leaves open translation to human deconditioning after spaceflight or bed rest.
Does hindlimb unloading enhance sympathoinhibitory responses to volume expansion in rats?
Absolute Event Rate: -46% vs -25%
Hindlimb unloading in rats enhances sympathoinhibitory responses to volume expansion, suggesting augmented cardiopulmonary reflexes may contribute to cardiovascular deconditioning after spaceflight or bed rest.
Mueller et al. (2003) studied Cardiovascular deconditioning. Hindlimb unloading (HU) vs. Control animals was evaluated on Renal sympathetic nerve activity (RSNA) response to isotonic volume expansion. Hindlimb-unloaded rats exhibited a significantly greater decrease in renal sympathetic nerve activity in response to volume expansion compared to controls (-46% vs. -25%).
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