Key result
Vascular surgery significantly altered hemostatic and fibrinolytic pathways 6-12 hours postoperatively, including decreased factor VIII (158.0 vs 103.3, P<0.001) and increased D-dimer (P=0.005).
Why the study?
The study was designed to assess the impact of vascular procedures on the activity of hemostatic and fibrinolytic pathways.
Does vascular surgery alter hemostatic and fibrinolytic pathways in patients with abdominal aortic aneurysm or peripheral artery disease?
Population
38 patients aged ≥ 45 years undergoing surgery for abdominal aortic aneurysm or peripheral artery disease
Comparison
Postoperative (6-12h after vascular procedure) vs preoperative baseline
Design
Pilot study
Follow-up
6-12h after vascular procedure
Authors
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Vascular procedures alter hemostatic markers; leaves open whether changes affect thrombotic risk or warrant targeted monitoring in larger trials.
Observational (n=38)
Does vascular surgery alter hemostatic and fibrinolytic pathways in patients with abdominal aortic aneurysm or peripheral artery disease?
Absolute Event Rate: 103.3% vs 158%
p-value: p=<0.001
Vascular surgery for abdominal aortic aneurysm or peripheral artery disease leads to significant acute alterations in hemostatic and fibrinolytic biomarkers.
Polok et al. (2019) conducted an observational in Abdominal aortic aneurysm or peripheral artery disease (n=38). Vascular surgery vs. Preoperative baseline was evaluated on Factor VIII levels (p=<0.001). Vascular surgery significantly altered hemostatic and fibrinolytic pathways 6-12 hours postoperatively, including decreased factor VIII (158.0 vs 103.3, P<0.001) and increased D-dimer (P=0.005).
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