Key result
Patients with newly diagnosed type 2 diabetes mellitus had significantly lower 24-hour urinary endothelin-1 excretion compared to normal subjects (14.2 vs 25.0 pmol; p<0.05).
Why the study?
Is urinary Endothelin-1 excretion altered in patients with newly diagnosed type 2 diabetes mellitus compared to normal subjects?
Case-Control (n=32)
Is urinary Endothelin-1 excretion altered in patients with newly diagnosed type 2 diabetes mellitus compared to normal subjects?
Absolute Event Rate: 14.2% vs 25%
p-value: p=<0.05
Decreased urinary excretion of ET-1 in patients with recent-onset type 2 diabetes suggests a potential role of ET-1 in the pathogenesis of early diabetic nephropathy.
Should not alter ET-1 assessment in new T2DM; hypothesis-generating for its role in early diabetic nephropathy.
Endothelin-1 (ET-1) causes dramatic vasoconstriction and reduction of renal blood flow, with a decreased glomerular filtration rate (GFR). Early diabetic nephropathy is characterized by elevation of GFR and the formation of intrarenal microaneurysms. However, the mechanisms are unclear. To elucidate the pathophysiologic significance of urinary ET-1 in early diabetic nephropathy, the 24-h urinary excretion of ET-1 in 12 normal subjects and 20 patients with newly diagnosed type 2 diabetes mellitus were determined by a highly sensitive radioimmunoassay. The 24-h urinary ET-1 excretion in patients with diabetes mellitus (14.2 +/- 3.1 pmol, mean +/- SEM) was significantly lower (p < 0.05) than that of normal subjects (25.0 +/- 3.7 pmol). This decrease in urinary excretion of ET-1 in patients with recent-onset diabetes mellitus suggests a possible role of ET-1 in the pathogenesis of early diabetic nephropathy.
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Lam et al. (1995) conducted a case-control in Type 2 diabetes mellitus (n=32). Type 2 diabetes mellitus vs. Normal subjects was evaluated on 24-h urinary excretion of ET-1 (p=<0.05). Patients with newly diagnosed type 2 diabetes mellitus had significantly lower 24-hour urinary endothelin-1 excretion compared to normal subjects (14.2 vs 25.0 pmol; p<0.05).
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