Key result
TGF-beta1-induced proliferation and JNK1 activation in rat aortic smooth muscle cells require the secretion of thrombospondin and ligation of alpha(v)beta(3)-integrins.
TGF-beta1-induced proliferation of vascular smooth muscle cells is partially mediated by autocrine secretion of thrombospondin and ligation of alpha(v)beta(3)-integrins.
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Hypothesis-generating for TSP-1/αvβ3 as VSMC targets; leaves open translation to human vascular disease.
Sajid et al. (2000) studied this question. TGF-beta1 was evaluated on Proliferation of RASMC and JNK1 activity. TGF-beta1-induced proliferation and JNK1 activation in rat aortic smooth muscle cells require the secretion of thrombospondin and ligation of alpha(v)beta(3)-integrins.
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