Key result
Priming the AN69 ST membrane-equipped hemodialyzer with heparin demonstrated potent anticoagulant properties in preclinical sheep models, potentially allowing for a drastic reduction in heparin consumption.
Why the study?
Does the AN69 ST membrane primed with heparin act as a potent anticoagulant in preclinical models?
Does the AN69 ST membrane primed with heparin act as a potent anticoagulant in preclinical models?
Preclinical studies show the AN69 ST hemodialysis membrane can bind heparin and act as a potent anticoagulant, potentially reducing systemic heparin needs.
Should not yet change heparin dosing in hemodialysis; hypothesis-generating for AN69 ST priming in clinical trials.
The AN69 ST membrane was designed to render the surface of the native polyacrylonitrile polymer less cationic. This was achieved by layering the membrane with the polycationic biopolymer polyethyleneimine. This new membrane is able to bind heparin to its surface, through electrical interactions, without altering the reactivity of the sulfonate groups of the membrane, regularly distributed in the membrane bulk. The kinetics of unfractionated or low-molecular-weight heparins were studied in vitro and in vivo in sheep. Encouraging results were obtained indicating that heparin-coated hemodialyzers are potent anticoagulants. Priming the AN69 ST membrane-equipped hemodialyzer with heparin, as in regular hemodialysis, could allow drastic reduction of heparin consumption in hemodialysis.
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Chanard et al. (2005) studied Hemodialysis. AN69 ST membrane with heparin was evaluated on Kinetics of unfractionated or low-molecular-weight heparins. Priming the AN69 ST membrane-equipped hemodialyzer with heparin demonstrated potent anticoagulant properties in preclinical sheep models, potentially allowing for a drastic reduction in heparin consumption.