Key result
Indomethacin, ETA, and PPP reduced the tone of isolated human umbilical arteries, suggesting that intramural synthesis of prostaglandins contributes to the maintenance of arterial tone.
Prostaglandin synthetase inhibitors and antagonists reduce the tone of isolated human umbilical arteries, suggesting intramural prostaglandin synthesis contributes to the maintenance of arterial tone.
No clinical implications for umbilical artery tone; leaves open intramural prostaglandin contribution in intact human vasculature.
The effects of 2 prostaglandin synthetase inhibitors, indomethacin and eicosa-5,8,11,14-tetraynoic acid (ETA) and of the prostaglandin antagonist, polyphloretin phosphate (PPP), on the tone of the isolated human umbilical artery and on the responses of this preparation to 5-hydroxytryptamine (5-HG) and prostaglandin F2alpha (PGF2alpha) were investigated. Indomethacin (8 mug/ml), ETA (5 mug/ml) or PPP (40 mug/ml) reduced the tone of human umbilical arteries but had no influence on the responses to 5-HT. In these concentrations ETA and PPP but not indomethacin antagonized the action of PGF2alpha. When the concentration of indomethacin or PPP was increased 5-fold both 5-HT- and PGF2alpha-induced contractions were antagonized indicating a non-specific inhibition at these concentration levels. A 10-fold increase in the concentration of ETA had no antagonizing action on 5-HT-induced contractions suggesting a more selective inhibition of the PGF2alpha action than displayed by the other compounds. The effects on the tone of the human umbilical artery of the compounds studied might reflect inhibition of prostaglandin biosynthesis and/or antagonism of the action of formed prostaglandins. The findings are compatible with the view that intramural synthesis of prostaglandins contributes to the maintenance of the tone of the isolated human umbilical artery.
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Strandberg et al. (1975) studied Isolated human umbilical artery. Indomethacin, eicosa-5,8,11,14-tetraynoic acid (ETA), and polyphloretin phosphate (PPP) was evaluated on Tone of the isolated human umbilical artery and responses to 5-HT and PGF2alpha. Indomethacin, ETA, and PPP reduced the tone of isolated human umbilical arteries, suggesting that intramural synthesis of prostaglandins contributes to the maintenance of arterial tone.
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