Why the study?
Does indomethacin increase venoconstriction to alpha1- and alpha2-stimulation in normal human subjects?
Does indomethacin increase venoconstriction to alpha1- and alpha2-stimulation in normal human subjects?
Indomethacin enhances alpha1- and alpha2-adrenoceptor-mediated venoconstriction in humans, indicating that venous adrenergic stimulation releases vasodilator prostaglandins that modulate the sympathetic response.
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May modulate venous alpha-adrenergic responses with NSAID use; leaves open clinical relevance in patients.
Callow et al. (1998) studied this question.
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