Why the study?
Does local indomethacin infusion increase venoconstriction to physiological stress in normal subjects and patients with chronic heart failure?
Population
25 subjects total: 11 normal subjects and 14 patients with chronic heart failure.
Comparison
Local indomethacin infusion in one hand during… vs Saline infusion in the other hand.
Design
Other
Authors
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Prostaglandin inhibition augments venoconstriction to stress; extends mechanistic evidence in CHF but leaves clinical relevance open.
Does local indomethacin infusion increase venoconstriction to physiological stress in normal subjects and patients with chronic heart failure?
Inhibition of prostaglandins by indomethacin significantly enhances hand vein constriction to physiological stimuli in both normal subjects and heart failure patients, demonstrating the role of prostaglandins in modulating vascular tone.
Dzeka et al. (2003) studied this question.
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