Why the study?
Does local infusion of endothelin-1 increase venoconstriction in patients with essential hypertension compared to normotensive controls?
Population
24 subjects: 12 patients with essential hypertension and 12 age, sex, weight, and height matched…
Comparison
Local infusion of endothelin-1 and… vs Normotensive control subjects receiving the same…
Design
Case-control
Authors
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May implicate endothelin pathways in early hypertensive venous changes; hypothesis-generating and requires prospective validation.
Does local infusion of endothelin-1 increase venoconstriction in patients with essential hypertension compared to normotensive controls?
Patients with essential hypertension exhibit enhanced venoconstriction to endothelin-1, which may contribute to reduced venous compliance and altered systemic hemodynamics in early hypertension.
Haynes et al. (1994) studied this question.
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