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BACKGROUND: Slowly progressive asymmetric parkinsonism and cortical dysfunction clinically characterize corticobasal syndrome (CBS). Various pathologic findings, including corticobasal degeneration (CBD), progressive supranuclear palsy, and frontotemporal degenerations, underlie CBS. OBJECTIVE: To determine if regional cortical and corpus callosum atrophy and subcortical and periventricular white matter (SPWM) signal changes on head magnetic resonance imaging were specific to CBD. DESIGN: Historical review of autopsy cases. SETTING: Subspecialized behavioral neurology and movement disorder clinics within a neurology department of a tertiary referral center. PATIENTS: Seventeen patients with CBS who had an autopsy-confirmed diagnosis of CBD or another neurodegenerative disease. MAIN OUTCOME MEASURES: Regional cerebral cortical atrophy, regional corpus callosum atrophy, and SPWM signal changes. RESULTS: Similar patterns of regional atrophy and SPWM signal changes were found in the patients with autopsy-proven CBD and in the patients with other neurodegenerative diseases. CONCLUSION: Neither cortical nor corpus callosum atrophy nor SPWM signal changes on head magnetic resonance imaging are specific to CBD.
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Josephs et al. (2004) studied this question.
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