Key result
Serum levels of D-dimer, fibrinogen, Troponin-I, and CRP were significantly elevated in patients with acute pulmonary embolism compared to those without (p<0.05 for all).
Why the study?
Acute pulmonary embolism is a serious, potentially fatal cardiovascular emergency, prompting evaluation of whether combined serum markers could serve as a diagnostic tool.
Do serum markers (CRP, D-dimer, fibrinogen, Troponin-I) differentiate patients with acute pulmonary embolism from those without?
Cross-Sectional (n=96)
No
Do serum markers (CRP, D-dimer, fibrinogen, Troponin-I) differentiate patients with acute pulmonary embolism from those without?
A combination of serum markers including D-dimer, Troponin-I, and CRP may aid in the diagnosis of acute pulmonary embolism in resource-limited settings.
Serum marker elevations may support APE suspicion; leaves open whether combinations enhance diagnosis beyond D-dimer in validated cohorts.
Background and objective Acute pulmonary embolism (APE) is a serious cardiovascular emergency, mainly secondary to deep vein thrombosis (DVT), which causes death. The goal of the current study was to determine the levels of different serum markers in combination among patients with and without acute pulmonary embolism in order to use them as a diagnostic tool. Methodology A sample of 96 patients was kept with a 90% power of study and a 5% level of significance in the current study. It was carried from January to June 2020 in the Department of Medicine, Bahawal Victoria Hospital, Bahawalpur, after the hospital's Ethical Committee approval. Written informed consent was taken. Serum levels of C-reactive protein (CRP), D-dimer, fibrinogen, and Troponin-I between both groups were done once enrolled. SPSS software, version 25 (IBM Corp. Armonk, NY) was used to analyze the collected data. Results Patients with acute pulmonary embolism had a mean age of 50.4 ± 10.4 years. All serum markers were significantly raised in patients suffering from acute pulmonary embolism with a p-value of <0.05. Conclusion We concluded that all these serum markers can be used together as a tool in making the correct diagnosis of acute pulmonary embolism in our setup.
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Yousuf et al. (2020) conducted a cross-sectional in Acute pulmonary embolism (n=96). Serum markers (CRP, D-dimer, fibrinogen, Troponin-I) vs. Patients without acute pulmonary embolism was evaluated on Serum levels of CRP, D-dimer, fibrinogen, and Troponin-I (p=<0.05). Serum levels of D-dimer, fibrinogen, Troponin-I, and CRP were significantly elevated in patients with acute pulmonary embolism compared to those without (p<0.05 for all).
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