Key result
Higher mean platelet volume-to-lymphocyte ratio was associated with the presence of left ventricular apical thrombus post-myocardial infarction (AUC 0.811; 95% CI 0.731-0.891; p<0.001).
Why the study?
The thrombo-inflammatory process plays an important role in post-myocardial thromboembolic complications, but the prognostic significance of the mean platelet volume to lymphocyte ratio in patients with apical thrombus was unknown.
Does the mean platelet volume-to-lymphocyte ratio (MPVLR) predict the presence of left ventricular apical thrombus in post-myocardial infarction patients?
Case-Control (n=107)
Does the mean platelet volume-to-lymphocyte ratio (MPVLR) predict the presence of left ventricular apical thrombus in post-myocardial infarction patients?
MPVLR is a simple, accessible biomarker that independently predicts the formation of left ventricular apical thrombus in patients following an anterior myocardial infarction.
May support PLR as thrombo-inflammatory marker in apical thrombus; hypothesis-generating, requires prospective validation before clinical use.
Background Left ventricular apical thrombus (AT) is generally associated with ischemic and non-ischemic cardiomyopathies. The thrombo-inflammatory process plays an important role in the pathophysiology of acute coronary syndromes and post-myocardial thromboembolic complications. Mean platelet volume (MPV) has been linked to poor prognosis following myocardial infarction. Recently, platelet-to-lymphocyte ratio (PLR) has emerged as a new marker of worse outcomes linking inflammation and thrombosis. Objective We aimed to investigate the prognostic significance of the marker – mean platelet volume to lymphocyte ratio (MPVLR) in patients with AT. Methods Fifty-six patients with left ventricular AT after an anterior myocardial infarction and 51 patients without left ventricular AT after an anterior myocardial infarction were enrolled in this study retrospectively. Admission MPVLR was compared between the two groups. Logistic regression analysis was carried out to identify whether MPVLR is an independent predictor of AT. The receiver operating curve (ROC) analysis was used to show the optimal cut-off for MPVLR to predict AT. P values less than 0.05 were considered statistically significant. Results Age, gender, frequency of diabetes mellitus, hypertension and atrial fibrillation, and ejection fraction values did not differ between the groups. MPVLR was higher in patients with AT than patients without AT (7.91±2.5 vs 5.1±2.1, p<0.001). ROC analysis revealed moderate diagnostic value in predicting the presence of AT with a MPVLR cut-off > 4.75 (82.1% sensivity and 70.2% specifity (area under the curve=0.811, 95% confidence interval [CI]: 0.731-0.891, p<0.001). MPVLR was found to be an independent risk factor for the formation of AT (B:0.441, p.0.001). Conclusion MPVLR is a simple, cheap and easily accessible test that can predict left ventricular AT formation. (Int J Cardiovasc Sci. 2020; [online].ahead print, PP.0-0)
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Köseoğlu et al. (2020) conducted a case-control in Left ventricular apical thrombus after anterior myocardial infarction (n=107). Mean platelet volume-to-lymphocyte ratio (MPVLR) vs. Patients without left ventricular apical thrombus was evaluated on Presence of left ventricular apical thrombus (AUC 0.811, 95% CI 0.731-0.891, p=<0.001). Higher mean platelet volume-to-lymphocyte ratio was associated with the presence of left ventricular apical thrombus post-myocardial infarction (AUC 0.811; 95% CI 0.731-0.891; p<0.001).
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