Answers are grounded in this paper and cite their sources.
A new synthesis of the antipsychotic ziprasidone from 2,5-dichloro-4-nitrotoluene 3 is presented. The nitro group in 3 was used to activate the ortho-chlorine for displacement and the methyl group for enamine formation and introduction of the piperazinyl moiety.
No takes yet. Share an insight, caveat, or question.
Urban et al. (1996) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: