Retrospective Study to Assess the Effect of Telmisartan on Urine Albumin-To-Creatinine Ratio (UACR) in Indian Hypertensive Patients with Diabetes

Introduction: Hypertension (HTN) is one of the major causes of Chronic Kidney Disease (CKD).Impaired kidney function and kidney damage can be detected by albuminuria.This study was aimed at assessing the effect of Telmisartan monotherapy on urine albumin-to-creatinine ratio (UACR) among Indian hypertensive patients. Materials and Methods:This was a retrospective cohort study.Data was collected retrospectively from 161 centres across India between Feb 2015 to Feb 2021.Hypertensive patients on Telmisartan monotherapy with UACR records available of at least two analyzable visits were enrolled.Demographic, clinical, treatment and outcome data of hypertensive patients meeting the inclusion criteria were captured.Mean changes in UACR and blood pressure (BP) from visit 1 to visit 2 were assessed.Results: Data of 1095 patients was available for analysis.The mean age was 54.0±11.7 years with 615 males and 480 females.The mean interval between Visit 1 and 2 was 278.06 days with a mean UACR 113.58 mg/g at Visit 1 and 77.29 mg/g at Visit 2 (mean difference of -36.29 mg/g, p=0.0012).The mean UACR in diabetic patients (n=945) was 83.3±312.4mg/g at visit 1 and 58.27±231.47 mg/g at visit 2 (difference -25.02 mg/g, p=0.0055, mean duration 292.06 days).The mean systolic BP at visit 1 and visit 2 was 142.23 and 133.71 mm/Hg (mean change -8.5 mm/Hg, p<0.001) and the mean diastolic BP at visit 1 and visit 2 was 83.77 and 80.04 mm/Hg (mean change -3.8 mm/Hg, p<0.001) respectively.Conclusion: Telmisartan can effectively reduce UACR and BP in Indian patients.It can be a promising treatment option to delay the progression of proteinuria in hypertensive patients.