Key result
Telmisartan-based therapy is linked to ~76 μg/min microalbuminuria reduction over 16 weeks.
Why the study?
The anti-hypertensive and anti-albuminuric effects of telmisartan alone and in combination with torasemide and amlodipine in hypertensive patients with persistent microalbuminuria were evaluated.
Does telmisartan alone or in combination with torasemide and amlodipine reduce microalbuminuria in hypertensive patients with persistent microalbuminuria?
Observational
Does telmisartan alone or in combination with torasemide and amlodipine reduce microalbuminuria in hypertensive patients with persistent microalbuminuria?
Mean Difference: 76.4
p-value: p=< 0.001
Telmisartan therapy significantly reduces microalbuminuria and blood pressure in hypertensive patients with persistent microalbuminuria, regardless of diabetes status.
May support telmisartan for microalbuminuria; hypothesis-generating and should not change practice without RCTs.
We evaluated the anti-hypertensive and anti-albuminuric effect of the angiotensin receptor blocker telmisartan alone and in combination with torasemide and amlodipine. Patients were hypertensive, both diabetics and non-diabetics with persistent microalbuminuria. Our primary endpoint was a change in microalbuminuria levels, while the secondary endpoints were changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), serum creatinine levels, and glomerular filtration rate.After the 16-week treatment period, the patients significantly reduced microalbuminuria levels (76.4 ± 52.4 μg/min; p < 0.001), SBP (16.4 ± 8.7 mmHg; p < 0.001) and DBP (17.7 ± 5.9 mmHg; p < 0.001). Both diabetics and non-diabetics showed an identical pattern of significance with respect to the whole population. Systolic blood pressure, DBP, and microalbuminuria were significantly reduced as a consequence of therapy, both in diabetics and non-diabetics.
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Rodríguez-Pérez et al. (2011) conducted an observational in Hypertension with persistent microalbuminuria. Telmisartan alone and in combination with torasemide and amlodipine was evaluated on change in microalbuminuria levels (MD 76.4, p=< 0.001). Telmisartan alone or in combination with torasemide and amlodipine significantly reduced microalbuminuria levels by 76.4 ± 52.4 μg/min (p < 0.001) over 16 weeks.
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