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A dinuclear Cu(II) complex with 1,3-bis(1,4,7-triaza-1-cyclononyl)propane cleaved plasmid DNA to relaxed circular and linear forms at pH 7.3 and 30 °C. Under the same conditions, double strand cleavage by the corresponding mononuclear Cu(II)([9]aneN3) complex was negligible.
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Kim et al. (2003) studied this question.
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