Key result
Large femoral vein grafts and small lateral saphenous vein grafts both demonstrated 100% patency and no significant difference in flow at up to 12 months in a canine model.
Why the study?
Does large vein graft diameter improve graft patency and flow compared to small vein grafts in a canine bypass model?
Does large vein graft diameter improve graft patency and flow compared to small vein grafts in a canine bypass model?
In a canine model, large and small vein grafts showed identical patency and flow, suggesting no physiological advantage to using smaller calf veins over larger thigh veins for bypass grafting.
No patency or flow advantage for larger grafts in canine model; leaves open optimal vein diameter selection for human bypass.
The purpose of this study was to examine the effects of vein graft diameter on graft patency and flow. In both legs of 12 dogs the (large) femoral vein and (small) lateral saphenous vein were bypassed onto their respective femoral arteries at identical levels. Graft flows and diameters were recorded, and early (10 days) and late (6 or 12 months) angiograms were performed. All 24 vein grafts were patent on both early and late studies. There was no statistically significant difference between large and small graft flows intraoperatively or at sacrifice (6 or 12 months). This study suggests that there is no advantage to the use of small calf veins over larger thigh veins for coronary artery bypass grafting.
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Morishita et al. (1983) studied Vein bypass graft (n=12). Large femoral vein graft vs. Small lateral saphenous vein graft was evaluated on Graft patency and flow. Large femoral vein grafts and small lateral saphenous vein grafts both demonstrated 100% patency and no significant difference in flow at up to 12 months in a canine model.
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