Key result
Commonly used anesthetic drugs, such as barbiturates, halothane, and isoflurane, have direct or prominent physiological effects modulated by KATP channels in myocardial preconditioning.
KATP channels play a crucial role in myocardial preconditioning and are modulated by commonly used anesthetic drugs.
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Anesthetic choice may affect myocardial preconditioning via KATP channels; leaves open whether this alters perioperative outcomes in practice.
Several factors have pointed to a potential link between ATP sensitive potassium channel activation in ventricular myocytes and the phenomenon of myocardial preconditioning. Preconditioning can be blocked by adenosine antagonists, and is mimicked by adenosine A1-receptor agonists. A portion of the physiological action of adenosine is, however attributable to adenosine actions on KATP channels. The adenosine A1 receptor is reported to be linked to the KATP channel in rat ventricular myocytes by a G-protein mechanism. This article will review the current status of work regarding the role of KATP channels in myocardial preconditioning and will highlight recent work addressing the role of anesthetic effects in these studies. Recent reports and work from our laboratory reveal that several commonly used anesthetic drugs either have direct effects on KATP channels (barbiturates) or have prominent physiological effects that are modulated in large part by KATP channels (volatile anesthetics halothane and isoflurane).
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Cason et al. (1995) conducted a review in Myocardial preconditioning. Anesthetic drugs (barbiturates, halothane, isoflurane) was evaluated. Commonly used anesthetic drugs, such as barbiturates, halothane, and isoflurane, have direct or prominent physiological effects modulated by KATP channels in myocardial preconditioning.
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