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Recent advances in CpxMIII catalysis (M=Co, Rh, Ir) have enabled a variety of enantioselective C(sp2)−H functionalization reactions, but enantioselective C(sp3)−H functionalization is still largely unexplored. We describe an asymmetric C(sp3)−H amidation of thioamides using an achiral CoIII/chiral carboxylic acid hybrid catalytic system, which provides easy and straightforward access to chiral β‐amino thiocarbonyl and β‐amino carbonyl building blocks with a quaternary carbon stereocenter.
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Fukagawa et al. (2018) studied this question.
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