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June 1, 1994Nucleosides and Nucleotides

Synthesis of 4-Amino-8-(2, 2-Difluoro-2-Deoxy-β-D-Ribo Furanosyl Amino)Pyrimido [5, 4-D]Pyrimidine (dFARPP). Stability and Cellular Cytotoxicity

Thomas E. Mabry C. David Jones Tse‐Chuan Chou Joseph M. Colacino Gerald B. Grindey John F. Worzalla Homer L. Pearce

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Abstract

The synthesis of β-dFARPP was accomplished by Mitsunobu coupling of 6-cyanopurine with 2-deoxy-2, 2-difluororibose followed by purine ring-expansion under the action of methanolic ammonia. The title compound inhibited the growth of proliferating human leukemic CCRF-CEM cells at 6.1μg/ml but had no effect on plaque formation by a variety of DNA and RNA viruses.

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Mabry et al. (1994) studied this question.

synapsesocial.com/papers/6a9377cb8b8d19994f5b362b https://doi.org/10.1080/15257779408011883

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