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Shrinking the circle: Complex cyclohexanol derivatives with up to four new stereogenic centers are easily obtained by simple one-pot, three-component, zirconium-mediated coupling of an alkyllithium or Grignard reagent, a seven-membered cyclic enol ether, and an electrophile (E, see scheme).
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Barluenga et al. (2007) studied this question.
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