Key result
Autoimmune-related phenomena were present in 59.5% of women with lichen sclerosus et atrophicus, but did not significantly alter the natural history of the disease.
Observational (n=350)
A high prevalence of autoimmune phenomena is observed in women with lichen sclerosus et atrophicus, though it does not significantly impact the natural history of the disease.
High autoimmune prevalence in LSA lacks prognostic impact; leaves open screening utility and mechanistic trials.
A study of autoimmune related phenomena in 350 women with histologically confirmed lichen sclerosus et atrophicus revealed that 21.5% had one or more autoimmune related diseases, 21% had one or more first degree relatives with an autoimmune-related disease, 42% had an autoantibody at a titre greater than 1:20, and 59.5% had one or more of these autoimmune-related phenomena. No statistically significant differences in the natural history of lichen sclerosus et atrophicus were demonstrated between those patients with autoimmune-related phenomena and those without.
No takes yet. Share an insight, caveat, or question.
Thomas et al. (1988) conducted an observational in Lichen sclerosus et atrophicus (n=350). Autoimmune-related phenomena vs. No autoimmune-related phenomena was evaluated on Differences in the natural history of lichen sclerosus et atrophicus. Autoimmune-related phenomena were present in 59.5% of women with lichen sclerosus et atrophicus, but did not significantly alter the natural history of the disease.