A potent and specific phosphoinositide 3-kinase inhibitor (±)-wortmannin has been achieved through an intramolecular Heck reaction for the construction of an allylic quaternary carbon center and a diosphenol–Claisen rearrangement (see scheme). SEM=2-(Trimethylsilyl)ethoxymethyl.
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Mizutani et al. (2002) studied this question.
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