Enantioselective Organocatalytic Hydrophosphination of α,β‐Unsaturated Aldehydes

Keeping it simple: Optically active phosphine derivatives can be obtained in high yields and in up to 99 % ee by using simple chiral amines to catalyze the hydrophosphination of α,β-unsaturated aldehydes (see scheme, green sphere=chiral group). The synthetic utility of this highly chemo- and enantioselective transformation was exemplified by the one-pot asymmetric synthesis of β-phosphine oxide acids.