PdII-Catalyzed Cyclization of Alkynes Containing Aldehyde, Ketone, or Nitrile Groups Initiated by the Acetoxypalladation of Alkynes

The insertion of carbonyl or nitrile units into a carbon–palladium bond has been achieved under mild reaction conditions (see scheme). The PdII-catalyzed system, which does not require organometallic reagents, redox systems, or additives to obtain a high yield of cyclized product, is effective with a wide variety of functionalized alkyne compounds.