Camptodactyly, cleft palate, and club foot. A syndrome showing the autosomal-dominant pattern of inheritance.

Camptodactyly is the name introduced by Landouzy (1906) for one of the varieties of con- stitutionally crooked digits. Camptodactyly almost always affects the fifth finger, the characteristic lesion being a flexion contracture of the proximal interphalangeal joint. The degree of flexion may vary from a very slight deformity to an almost right-angled bend; it is seldom more than this. The fourth to second fingers, in decreasing order of fre- quency, may be affected similarly, the extent of the deformity being progressively less in the more radial fingers. Often there is hyperextension of the meta- carpophalangeal joints of the affected fingers, and occasionally the proximal interphalangeal joints of some fingers are also hyperextended. Rarely there is flexion deformity of the terminal interphalangeal joints as well. Involvement of the thumb is unusual. In advanced cases, there is ulnar deviation of the affected fingers, with radial rotation of the fifth fin- ger, and the palm becomes cup-shaped. Longi-