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A homogenate of a biopsy specimen of liver obtained from a patient with phenylpyruvic oligophrenia did not catalyze detectable conversion of phenylalanine to tyrosine, under conditions whereby liver homogenates obtained from normal individuals were active in catalyzing such conversion. Addition of a fraction prepared from rat liver (which exhibited relatively low activity alone) to the inactive phenylketonuric liver homogenate resulted in striking activation of the conversion of phenylalanine to tyrosine.
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Wallace et al. (1957) studied this question.
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