Paroxysmal Nocturnal Hemoglobinuria Revisited

Immunologic systems are now known to have a major role in the pathophysiology of many human disease processes. One such system is serum complement. Complement is one of several plasma protein systems that consists of a series of circulating precursor proteins and regulatory molecules. Biologically active products are generated during complement activation, and the delineation of these products has helped to define the critical role of complement in human biology. Similarly, an understanding of the function of these molecules has established complement as an important participant in the pathophysiology and clinical expression of several human diseases. One such disease is . . .