Key result
NSLF6, an optimized combination of total ginsenosides and total salvianolic acids, significantly reduced myocardial injury markers and promoted angiogenesis in rat models of myocardial infarction.
Why the study?
Does NSLF6 improve myocardial infarction outcomes and promote angiogenesis in preclinical models?
Does NSLF6 improve myocardial infarction outcomes and promote angiogenesis in preclinical models?
NSLF6, an optimized composition derived from traditional Chinese medicine, demonstrates cardioprotective effects in preclinical models of myocardial infarction by promoting angiogenesis and reducing oxidative damage.
Answers are grounded in this paper and cite their sources.
Cautions against clinical use of NSLF6; leaves open its angiogenic effects in MI pending human trials.
BACKGROUND: Shuanglong formula (SLF), a Chinese medicine composed of panax ginseng and salvia miltiorrhiza exhibited significant effect in the treatment of myocardial infarction (MI) in clinical. Because of the complex nature and lack of stringent quality control, it's difficult to explain the action mechanism of SLF. METHOD: In this study, we present a "system to system" (S2S) mode. Based on this mode, SLF was simplified successively through bioactivity-guided screening to achieve an optimized minimal phytochemical composition (new formula NSLF6) while maintaining its curative effect for MI. RESULTS: Pharmacological test combining with the study of systems biology show that NSLF6 has activity for treatment MI through synergistic therapeutic efficacies between total ginsenosides and total salvianolic acids via promoting cardiac cell regeneration and myocardial angiogenesis, antagonistic myocardial cell oxidative damage. CONCLUSIONS: The present S2S mode may be an effective way for the discovery of new composite drugs from traditional medicines.
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Liang et al. (2012) studied Myocardial infarction (preclinical models). NSLF6 (total ginsenosides and total salvianolic acids) vs. Model group (vehicle) and positive controls was evaluated on Myocardial injury markers (CK, LDH, NEFA), infarct area, and metabolomic/genomic profiles (p=<0.05). NSLF6, an optimized combination of total ginsenosides and total salvianolic acids, significantly reduced myocardial injury markers and promoted angiogenesis in rat models of myocardial infarction.
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