Key result
Shenlian extract reduced apoptosis, infarct size, and myocardial injury markers in a mouse model of MI/R by inhibiting M1 macrophage polarization via down-regulating miR-155.
Why the study?
To explore the effect of Shenlian extract on myocardial ischaemia-reperfusion injury and its underlying mechanism.
Shenlian extract attenuates myocardial ischaemia-reperfusion injury in preclinical models by inhibiting M1 macrophage polarization via down-regulating miR-155.
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Does not support clinical use in MI/R; leaves open human translation of Shenlian extract.
Song et al. (2022) studied Myocardial ischaemia-reperfusion injury. Shenlian extract (SL) was evaluated on Myocardial tissue injury and M1 macrophage polarization. Shenlian extract reduced apoptosis, infarct size, and myocardial injury markers in a mouse model of MI/R by inhibiting M1 macrophage polarization via down-regulating miR-155.
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