September 1, 2024Science of Traditional Chinese MedicineOpen Access

Improvement of myocardial fibrosis injury by Shengmai injection in ischemia-induced heart failure in a rat model

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Myocardial fibrosis injury decreases substantially following Shengmai injection, and overall cardiac function improves markedly during heart failure progression.
Within 35 days of treatment, circulating levels of collagen 1a1 and versican declined, and echocardiography confirmed substantial recovery of ejection fraction.
Left anterior descending coronary artery ligation in rats enabled targeted validation, and cultured H9c2 cells were exposed to angiotensin ii to assess cell viability.
These results highlight an antifibrotic role for Shengmai injection in ischemic heart failure, though rat model constraints require further clinical validation.

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Implication

Preclinical study demonstrates reduced myocardial fibrosis and enhanced cardiac function with Shengmai injection in ischemic rats, highlighting an antifibrotic mechanism.

Cite This Study

Ding et al. (2024) studied this question.

synapsesocial.com/papers/68e59d88b6db643587537f61 https://doi.org/10.1097/st9.0000000000000040

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Implication

Preclinical study demonstrates reduced myocardial fibrosis and enhanced cardiac function with Shengmai injection in ischemic rats, highlighting an antifibrotic mechanism.

Improvement of myocardial fibrosis injury by Shengmai injection in ischemia-induced heart failure in a rat model

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Discussion

Implication

Cite This Study

Improvement of myocardial fibrosis injury by Shengmai injection in ischemia-induced heart failure in a rat model

Key Points

Discussion

Implication

Cite This Study

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