January 1, 2018Cellular Physiology and BiochemistryOpen Access

Shenxian-Shengmai Oral Liquid Reduces Myocardial Oxidative Stress and Protects Myocardium from Ischemia-Reperfusion Injury

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Why the study?

Does Shenxian-shengmai (SXSM) oral liquid improve cardiac function and reduce oxidative stress in a rat model of myocardial ischemia-reperfusion injury?

Structured PICO

Does Shenxian-shengmai (SXSM) oral liquid improve cardiac function and reduce oxidative stress in a rat model of myocardial ischemia-reperfusion injury?

Population

Adult male Sprague Dawley (SD) rats and neonatal rat cardiomyocytes

Intervention

Shenxian-shengmai (SXSM) oral liquid administered orally by gavage for 14 days (in vivo) and SXSM serum (in vitro)

Comparator

Equivalent deionized water (in vivo control), ischemic preconditioning (IPC) as positive control, and hearts without I/R injury as normal control

Outcome

Heart rate (HR), left ventricular developed pressure (LVDP), the maximal increase rate of left ventricular pressure (+dp/dtmax) and the maximal decrease rate of left ventricular pressure (-dp/dtmax) during myocardial reperfusionsurrogate

Shenxian-shengmai oral liquid protects against myocardial ischemia-reperfusion injury and improves cardiac function in rats by reducing oxidative stress via SOD1 and GCLC pathways.

Discussion

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Implication

SXSM may attenuate myocardial I/R injury in animals; leaves open any clinical role in human bradyarrhythmias or reperfusion.

Cite This Study

Zhao et al. (2018) studied this question.

synapsesocial.com/papers/6a75eecd82e22d88278b71ca https://doi.org/10.1159/000492688

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Shenxian-Shengmai Oral Liquid Reduces Myocardial Oxidative Stress and Protects Myocardium from Ischemia-Reperfusion Injury

Structured PICO

Discussion

Implication

Cite This Study

Shenxian-Shengmai Oral Liquid Reduces Myocardial Oxidative Stress and Protects Myocardium from Ischemia-Reperfusion Injury

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider