January 20, 2017Open Access

Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits.

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Why the study?

Does Shenxianshengmai (SXSM) improve heart rate in a rabbit model of bradycardia?

Structured PICO

Does Shenxianshengmai (SXSM) improve heart rate in a rabbit model of bradycardia?

Population

24 adult rabbits (Oryctolagus cuniculus) with mean body weight of 2.5 ± 0.5 kg, with bradycardia induced by formaldehyde application to the right atrium.

Intervention

Shenxianshengmai (SXSM) 275 mg·kg−1·d−1 administered orally for 4 weeks.

Comparator

Purified water administered orally (model group) and sham operation groups.

Outcome

Heart rate (RR interval) and gene/protein expression profiles.surrogate

In a rabbit model of bradycardia, Shenxianshengmai (SXSM) partially restored heart rate by modulating parasympathetic transmission, calcium handling, and myocardial energy metabolism.

Limitations

Cannot assume all changes in gene expression are coupled to the development of bradycardia
Cannot exclude the possibility that part of the gene expression modifications was associated with the SA lesion or secondary to the development of bradycardia

Discussion

No takes yet. Share an insight, caveat, or question.

Implication

SXSM may raise heart rate via ATP generation and autonomic gene shifts in rabbits; leaves open clinical translation pending human trials.

Cite This Study

Liu et al. (2017) studied this question.

synapsesocial.com/papers/6a761cbc2a0f43dfa870787f https://doi.org/10.4103/0366-6999.197999

View Full Paper

Ask AI

Bookmark

Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits.

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Molecular Mechanisms of Increased Heart Rate in Shenxianshengmai-treated Bradycardia Rabbits.

Structured PICO

Limitations

Discussion

Implication

Cite This Study

Also Consider

Also Consider