Key result
Various analytical methods, including spectrophotometric and chromatographic techniques, have been reported for the estimation of Ranolazine in synthetic mixtures.
This review summarizes various spectrophotometric and chromatographic techniques for the analytical estimation of the anti-ischemic drug ranolazine.
Reported methods enable ranolazine quantification in mixtures; extends analytical options but leaves open validation for clinical samples.
Ranolazine is a piperazine derivative is a new anti-ischemic drug for the treatment of angina. Ranolazine is to inhibit late INa thus preventing sodium overload of the cell. As a consequence, ranolazine prevents reverse mode sodium-calcium exchange and thus diastolic accumulation of calcium possibly resulting in improved diastolic tone and improved coronary blood flow. This review article represents the various analytical methods which has been reported for estimation of Ranolazine in synthetic mixture. The spectrophotometric techniques like fluorescent assay and area under curve spectroscopy; Chromatographic methods like HPLC, HPTLC and RP HPLC, GC, LC-MS, LC-MS/MS were reported.
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Patel et al. (2015) conducted a review in Angina. Analytical methods for Ranolazine was evaluated. Various analytical methods, including spectrophotometric and chromatographic techniques, have been reported for the estimation of Ranolazine in synthetic mixtures.
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