Key result
In pregnant rats, L-type calcium channel binding capacity increased by 14 days' gestation and persisted through labor, while mRNA expression decreased 3- to 10-fold during parturition.
Population
Pregnant rat myometrium and nonpregnant controls
Comparison
Pregnancy and parturition (physiological changes) vs Nonpregnant controls
Design
Preclinical
Authors
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Hypothesis-generating for myometrial calcium channel dynamics in labor; leaves open translation to human parturition.
The number of L-type calcium channels increases in pregnancy but does not change prior to or with the onset of myometrial contraction, while mRNA expression markedly decreases at parturition.
Mershon et al. (1994) studied Pregnancy and parturition. Pregnancy and parturition vs. Nonpregnant controls was evaluated on Expression of the alpha 1 subunit of the L-VDCC at the mRNA or protein level. In pregnant rats, L-type calcium channel binding capacity increased by 14 days' gestation and persisted through labor, while mRNA expression decreased 3- to 10-fold during parturition.
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