Key result
Generic propofol and Diprivan required similar mean drug doses (90 vs 90 microg kg-1 min-1) to maintain a bispectral index of 50-65 in women undergoing abdominal hysterectomy.
Why the study?
Does generic propofol have similar efficacy and dose requirements compared to Diprivan in women undergoing abdominal hysterectomy?
RCT (n=60)
Double-blind
randomized
Does generic propofol have similar efficacy and dose requirements compared to Diprivan in women undergoing abdominal hysterectomy?
Absolute Event Rate: 90% vs 90%
Generic propofol and Diprivan have similar efficacy and dose requirements for maintaining a specified depth of anaesthesia.
Supports generic propofol substitution for Diprivan to reduce costs; confirms equivalent dosing for BIS-guided anesthesia in hysterectomy.
BACKGROUND AND OBJECTIVE: We compared the dose requirement and side effect profile of total intravenous anaesthesia using Diprivan to generic propofol at a specific anaesthetic target level utilizing the bispectral index monitor to determine efficacy differences between the two products. METHODS: Sixty women undergoing abdominal hysterectomy were induced with propofol 2 mg kg-1 and maintained with infusion (20-200 microg kg-1 min-1) adjusted to maintain a bispectral index of 50-65. Plasma propofol concentration was measured at 1 and 2 h post induction in 25 patients. RESULTS: Mean (SD) drug doses adjusted for weight and time were similar in the Diprivan and generic propofol groups: 90 (30) microg kg-1 min-1 vs. 90 (20) microg kg-1 min-1 respectively. Mean (SD) plasma propofol levels at 1 and 2 h were also similar (3.0 (1.0) microg mL-1 vs. 3.6 (1.4) microg mL-1, P = 0.2 and 3.0 (1.9) microg mL-1 vs. 3.4 (1.6) microg mL-1, P = 0.58). CONCLUSIONS: Diprivan and generic propofol have similar efficacy at a specified, bispectral index-defined, depth of anaesthesia.
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Olufolabi et al. (2006) conducted an RCT in abdominal hysterectomy (n=60). Generic propofol vs. Diprivan was evaluated on Mean drug dose adjusted for weight and time. Generic propofol and Diprivan required similar mean drug doses (90 vs 90 microg kg-1 min-1) to maintain a bispectral index of 50-65 in women undergoing abdominal hysterectomy.
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