Key result
COVID-19 vaccination may induce oxidative stress and inflammatory responses linked to exacerbated menopausal symptoms and menstrual irregularities.
Why the study?
The study was conducted to evaluate how oxidative stress and quality of life levels change after COVID-19 vaccination in menopausal females.
Menopause elevates CV-metabolic risk; leaves open targeted prevention trials in premature cases.
After 12 months of amenorrhea (absence of menses) and the irreversible termination of ovarian activity, menopause is identified. Menopause has a number of physiological implications, including increased abdominal obesity and a higher risk of cardiovascular and metabolic illness. Hot flashes (HF), headaches, back discomfort, stiff joints, weariness, and difficulty sleeping are all signs of menopause. Menopause begins around the age of 51. Menopause occurs prematurely in 0.3–1.1% of women. During menopause, oxidant stress (hydrogen peroxide and superoxidant anion) increases the formation of free radicals. Intermediates in enzymatic reactions that occur during cell metabolism (reactive oxygen species and reactive nitrogen) sometimes leak from enzyme molecules and interact with molecular oxygen, creating free oxygen free radicals. The molecular basis of cancer, neurodegenerative and cardiovascular diseases, diabetes, and autoimmune disorders is oxidative stress caused by free oxygen radicals. HF and irregular menses are common complaints among women, as seen in many blog entries, so there may be some research to be done. Oxidative stress causes COVID-19 post-vaccination side effects. Antioxidant supplements and menopausal hormonal treatment may lower oxidative stress and inflammation. The focus of this research is to see how oxidative stress and quality of life levels change after receiving the COVID-19 vaccination, which is used to treat HF associated with menopause.
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Deora et al. (2023) conducted a review in Menopause and COVID-19 vaccination side effects. COVID-19 vaccination was evaluated. COVID-19 vaccination may induce oxidative stress and inflammatory responses linked to exacerbated menopausal symptoms and menstrual irregularities.
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