Key result
Whole-porcine monoclonal antibodies HK24 and HK44 exhibited potent neutralizing activity against classical swine fever virus in vitro, with IC50 values of 9.3 μg/ml and 0.62 μg/ml, respectively.
Population
Single B cells sorted from a CSFV-vaccinated pig and PK-15 cells in vitro
Design
Preclinical
Authors
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These mAbs may support antibody-based CSFV control strategies; leaves open in vivo efficacy and clinical translation.
Two novel whole-porcine monoclonal antibodies (HK24 and HK44) isolated from single B cells demonstrated potent in vitro neutralizing activity against classical swine fever virus.
Dong et al. (2018) studied Classical swine fever virus (CSFV) infection. Whole-porcine monoclonal antibodies (HK24 and HK44) vs. Negative control was evaluated on Neutralizing activity against CSFV (IC50). Whole-porcine monoclonal antibodies HK24 and HK44 exhibited potent neutralizing activity against classical swine fever virus in vitro, with IC50 values of 9.3 μg/ml and 0.62 μg/ml, respectively.
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