Key result
AT1 and AT2 receptors were overexpressed in neoplastic epithelium of Gleason grade 2 prostate cancer, suggesting the involvement of the renin-angiotensin system in prostate cancerogenesis.
Observational (n=20)
The presence and overexpression of AT1 and AT2 receptors in early-grade prostate cancer suggests a potential role for the local renin-angiotensin system in prostate carcinogenesis.
May implicate local renin-angiotensin system in early prostate carcinogenesis; hypothesis-generating and requires human validation.
INTRODUCTION: The human prostate gland contains all the compounds of the renin-angiotensin system (RAS), including AT1 and AT2 angiotensin receptors. The role of local RAS in the prostate pathology is recently discussed. The aim of the present study was the evaluation of AT1 and AT2 expressions in human prostate cancers. MATERIAL AND METHODS: The investigation was performed in 20 paraffin-embedded needle biopsy specimens from routine diagnostic prostate cancer biopsies. The specimens were stained with hematoxylin and eosin and immunostained with anti-AT1 and anti-AT2 antibodies. For visualization of primary antibodies, the streptavidin-biotin-peroxidase technique was applied. The expression of both receptor proteins was evaluated quantitatively using image analysis method. RESULTS: The positive immunostaining with both anti- AT1 and anti-AT2 antibodies can be found in stromal as well as epithelial structures. The results of quantitative evaluation showed the positive correlation between AT1 and AT2 expressions in neoplastic epithelium and overexpression of both AT1 and AT2 in neoplastic epithelium of Gleason grade 2, but not in cancerous structures of Gleason grades 3-5. CONCLUSIONS: The data on AT1 and AT2 receptor expressions may suggest the involvement of RAS in prostate cancerogenesis. Moreover, the persistence of AT1 receptors in prostate cancer speaks in favor of attempts to use of AT1 receptor blockers (i.e. sartanes) and/or AT2 agonists in prostate cancer prophylaxis and/or treatment.
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Pawlikowski et al. (2011) conducted an observational in Prostate cancer (n=20). AT1 and AT2 receptor expression was evaluated on AT1 and AT2 expression in human prostate cancers. AT1 and AT2 receptors were overexpressed in neoplastic epithelium of Gleason grade 2 prostate cancer, suggesting the involvement of the renin-angiotensin system in prostate cancerogenesis.
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