Key result
Haemodialysis significantly reduced heart rhythm complexity (MSE area 10-20) from 20.22 before treatment to 18.91 after treatment in patients with end-stage renal disease (p=0.038).
Why the study?
Cardiovascular disease is a common complication in ESRD patients receiving haemodialysis, and a better understanding of their relationship is needed to improve life expectancy and reduce mortality.
Does haemodialysis affect heart rhythm complexity in end stage renal disease patients?
Observational (n=31)
No
Does haemodialysis affect heart rhythm complexity in end stage renal disease patients?
Absolute Event Rate: 18.9147% vs 20.2175%
p-value: p=0.038
Haemodialysis acutely reduces heart rhythm complexity in ESRD patients, suggesting a deleterious effect on autonomic nervous system regulation.
Cardiovascular disease (CVD) is one of the most common complications of end stage renal disease (ESRD) patients receiving haemodialysis (HD). A better understanding of the relationship between CVD and HD is important to improve life expectancy and reduce the mortality risk of ESRD patients receiving HD. Heart rate variability (HRV), also known as variations in heart rate, is a useful method to measure the autonomic nervous system dys-regulation with 24-h electrocardiogram (ECG). The variables of heart rhythm complexity could be acquired with multi-scale entropy analysis (MSE). We enrolled 31 ESRD patients receiving HD in this study. MSE was used as non-linear heart rate variability (HRV) in our study. MSE area was negative correlated with age. MSE area 10-20 was positive correlated with Kt/V, albumin (ALB) and hemoglobin (Hb). Furthermore, we found that the MSE area before HD was higher than the MSE area after HD. We also found that increased age was a deleterious factor of HRV in ESRD patients receiving HD. Kt/V, ALB, and Hb were beneficial factors of HRV in ESRD patients receiving HD. HD seemed to be a harmful factor of HRV in ESRD patients.
No takes yet. Share an insight, caveat, or question.
Sun et al. (2022) conducted an observational in End stage renal disease (n=31). Haemodialysis vs. Before haemodialysis was evaluated on Multi-scale entropy (MSE) area 10-20 (p=0.038). Haemodialysis significantly reduced heart rhythm complexity (MSE area 10-20) from 20.22 before treatment to 18.91 after treatment in patients with end-stage renal disease (p=0.038).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: