Role of Autonomic Nervous Dysfunction in Electrocardiographic Abnormalities and Cardiac Injury in Patients With Acute Subarachnoid Hemorrhage
Key result
Acute subarachnoid hemorrhage was associated with a 93% incidence of ECG abnormalities, alongside elevated cardiogenic enzymes, catecholamines, and enhanced vagal activity compared to the chronic phase.
Why the study?
What is the role of autonomic nervous dysfunction in electrocardiographic abnormalities and cardiac injury in patients with acute subarachnoid hemorrhage?
Population
84 subjects: 42 patients with acute-phase subarachnoid hemorrhage related to ruptured aneurysm and 42…
Comparison
Acute-phase subarachnoid hemorrhage vs Control subjects
Design
Case-control
Authors
Discussion
Loading...
Member takes
Implication
May warrant cardiac monitoring in acute SAH; leaves open autonomic dysfunction's causal role in ECG changes and injury.
Study Design
Type
Observational (n=84)
Multicenter
Yes
Structured PICO
What is the role of autonomic nervous dysfunction in electrocardiographic abnormalities and cardiac injury in patients with acute subarachnoid hemorrhage?
P
Population
84 participants, comprising 42 patients with acute subarachnoid hemorrhage and 42 age- and sex-matched controls, evaluated for autonomic nervous dysfunction and cardiac injury over a 30-day period.
E
Exposure
Acute-phase subarachnoid hemorrhage (observational exposure)
C
Comparator
Control subjects
O
Outcome
Electrocardiographic abnormalities, cardiac injury (cardiogenic enzymes: CK-MB, myosin light chain I, troponin T), and autonomic nervous function (HRV, plasma catecholamines)surrogate
Main Result
Absolute Event Rate: 93% vs 38%
Acute subarachnoid hemorrhage is associated with ECG abnormalities and cardiac injury, likely driven by both enhanced sympathetic and vagal activity.
Limitations
- Small sample size
- Lack of continuous HRV monitoring immediately from the exact time of onset prior to admission
- Potential confounding by varying degrees of intracranial pressure
Cite This Study
Kawahara et al. (2003) conducted an observational in Acute Subarachnoid Hemorrhage (n=84). Acute subarachnoid hemorrhage vs. Chronic phase (≥30 days) and matched controls was evaluated on Electrocardiographic (ECG) abnormalities. Acute subarachnoid hemorrhage was associated with a 93% incidence of ECG abnormalities, alongside elevated cardiogenic enzymes, catecholamines, and enhanced vagal activity compared to the chronic phase.