What question did this study set out to answer?

To evaluate anterior pituitary hormone secretion and assess the functional reserve of the hypothalamic-pituitary-gonadal axis in patients with Prader-Labhart-Willi syndrome.

December 1, 1974The Journal of Clinical Endocrinology & Metabolism

Anterior Pituitary Function in the Prader-Labhart-Willi (PLW) Syndrome

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Authors

GTG. TolisTulane University WLW.R. LewisWest Virginia University MVM VerdyPertamina (Indonesia)

Discussion

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Implication

Clinical investigation demonstrates variable hypothalamic-pituitary-gonadotropin axis function in Prader-Labhart-Willi syndrome, highlighting diverse endocrine functional reserves.

Key Points

To evaluate anterior pituitary hormone secretion and assess the functional reserve of the hypothalamic-pituitary-gonadal axis in patients with Prader-Labhart-Willi syndrome.
Assessed endocrine profiles in 5 patients (2 male, 3 female) with Prader-Labhart-Willi syndrome.
Measured baseline serum FSH, LH, prolactin, TSH, GH, estradiol, and testosterone, followed by provocation testing with TRH, LRH, clomiphene, and hCG.
Adrenal, thyroid, and growth hormone functions were normal, with normal baseline and TRH-stimulated TSH and prolactin levels in all patients.
LRH stimulation produced variable increases in serum FSH, LH, estradiol, and testosterone that correlated with sexual maturation, whereas clomiphene produced no hormonal response and hCG caused variable testosterone increases in males.

Cite This Study

Tolis et al. (1974) studied this question.

synapsesocial.com/papers/6a938f8887f8000eec56a62d https://doi.org/10.1210/jcem-39-6-1061

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December 1, 1974The Journal of Clinical Endocrinology & Metabolism

Anterior Pituitary Function in the Prader-Labhart-Willi (PLW) Syndrome

View Full Paper

Ask AI

Bookmark

Authors

GTG. TolisTulane University WLW.R. LewisWest Virginia University MVM VerdyPertamina (Indonesia)

Discussion

Member takes

Implication

Clinical investigation demonstrates variable hypothalamic-pituitary-gonadotropin axis function in Prader-Labhart-Willi syndrome, highlighting diverse endocrine functional reserves.

Key Points

To evaluate anterior pituitary hormone secretion and assess the functional reserve of the hypothalamic-pituitary-gonadal axis in patients with Prader-Labhart-Willi syndrome.
Assessed endocrine profiles in 5 patients (2 male, 3 female) with Prader-Labhart-Willi syndrome.
Measured baseline serum FSH, LH, prolactin, TSH, GH, estradiol, and testosterone, followed by provocation testing with TRH, LRH, clomiphene, and hCG.
Adrenal, thyroid, and growth hormone functions were normal, with normal baseline and TRH-stimulated TSH and prolactin levels in all patients.
LRH stimulation produced variable increases in serum FSH, LH, estradiol, and testosterone that correlated with sexual maturation, whereas clomiphene produced no hormonal response and hCG caused variable testosterone increases in males.

Cite This Study

Tolis et al. (1974) studied this question.

synapsesocial.com/papers/6a938f8887f8000eec56a62d https://doi.org/10.1210/jcem-39-6-1061

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