Key result
Closed-chest transauricular coronary coil embolization produced a similar infarct size compared to open-chest surgical ligation in a rabbit model of myocardial infarction.
Why the study?
Does a percutaneous closed-chest transauricular embolization model produce comparable experimental myocardial infarction to an open-chest surgical ligation model in rabbits?
Does a percutaneous closed-chest transauricular embolization model produce comparable experimental myocardial infarction to an open-chest surgical ligation model in rabbits?
A novel percutaneous transauricular coronary coil embolization model in rabbits produces comparable experimental myocardial infarction to standard open-chest surgical ligation, offering a less invasive platform for ischemia research.
Answers are grounded in this paper and cite their sources.
May facilitate less invasive rabbit ischemia models; leaves open translation beyond this preclinical setting.
INTRODUCTION: To date, most animal studies of myocardial ischemia have used open-chest models with direct surgical coronary artery ligation. We aimed to develop a novel, percutaneous, minimally-invasive, closed-chest model of experimental myocardial infarction (EMI) in the New Zealand White rabbit and compare it with the standard open-chest surgical model in order to minimize local and systemic side-effects of major surgery. METHODS: New Zealand White rabbits were handled in conformity with the "Guide for the Care and Use of Laboratory Animals" and underwent EMI under intravenous anesthesia. Group A underwent EMI with an open-chest method involving surgical tracheostomy, a mini median sternotomy incision and left anterior descending (LAD) coronary artery ligation with a plain suture, whereas Group B underwent EMI with a closed-chest method involving fluoroscopy-guided percutaneous transauricular intra-arterial access, superselective LAD catheterization and distal coronary embolization with a micro-coil. Electrocardiography (ECG), cardiac enzymes and transcatheter left ventricular end-diastolic pressure (LVEDP) measurements were recorded. Surviving animals were euthanized after 4 weeks and the hearts were harvested for Hematoxylin-eosin and Masson-trichrome staining. RESULTS: In total, 38 subjects underwent EMI with a surgical (n = 17) or endovascular (n = 21) approach. ST-segment elevation (1.90 ± 0.71 mm) occurred sharply after surgical LAD ligation compared to progressive ST elevation (2.01 ± 0.84 mm;p = 0.68) within 15-20 min after LAD micro-coil embolization. Increase of troponin and other cardiac enzymes, abnormal ischemic Q waves and LVEDP changes were recorded in both groups without any significant differences (p > 0.05). Infarct area was similar in both models (0.86 ± 0.35 cm in the surgical group vs. 0.92 ± 0.54 cm in the percutaneous group;p = 0.68). CONCLUSION: The proposed model of transauricular coronary coil embolization avoids thoracotomy and major surgery and may be an equally reliable and reproducible platform for the experimental study of myocardial ischemia.
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Katsanos et al. (2012) studied Experimental myocardial infarction (n=38). Closed-chest transauricular coronary embolization vs. Open-chest surgical coronary artery ligation was evaluated on Infarct size (cm) (p=0.68). Closed-chest transauricular coronary coil embolization produced a similar infarct size compared to open-chest surgical ligation in a rabbit model of myocardial infarction.
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