Comparative evaluation of conventional 5 mm inverse and micro inverse detection probes at 500 MHz

Performance and sensitivity characteristics of a standard 5 mm inverse detection probe and a new micro inverse detection probe design were compared on identical amounts of material at 500 MHz. The latter consistently afforded approximately twice the signal‐to‐noise performance of the former in two‐dimensional experiments, corresponding to a factor of four improvement in performance times to obtain comparable signal‐to‐noise ratio projections of HMQC data. The latter also facilitated the acquisition of HMQC spectra on much smaller amounts of material than was possible in the conventional 5 mm inverse detection probe.