Answers are grounded in this paper and cite their sources.
The synthesis of all the possible isomers of the eburnameninevincamine type alkaloids 1b , 2a , 3a and derivatives 4 , 8 , 9 , 10 is described. Structures were determined by 1 H‐ and 13 C‐NMR spectroscopy including special techniques such as DR, DEPT, DNOE, and 2D‐HSC. In contrast to the known cerebrovascular effects of cis ‐(3 S ,16 S ) compounds, trans ‐(3 S ,16 R ) derivatives show a significant peripheral vasodilator effect.
No takes yet. Share an insight, caveat, or question.
Czibula et al. (1993) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: